Nanopatterned Extracellular Matrices Enable Cell-Based Assays with a Mass Spectrometric Readout
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Nanopatterned Extracellular Matrices Enable Cell-Based Assays with a Mass Spectrometric Readout
Cell-based assays are finding wider use in evaluating compounds in primary screens for drug development, yet it is still challenging to measure enzymatic activities as an end point in a cell-based assay. This paper reports a strategy that combines state-of-the-art cantilever free polymer pen lithography (PPL) with self-assembled monolayer laser desorption-ionization (SAMDI) mass spectrometry to...
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ژورنال
عنوان ژورنال: Nano Letters
سال: 2017
ISSN: 1530-6984,1530-6992
DOI: 10.1021/acs.nanolett.6b04176